Crucial mutation of spike protein evolved to variant SARS-CoV-2 escape the neutralization of convalescent plasma and RBD-specific monoclonal antibodies. Chengchao Ding, Jun He, Xiangyu Zhang, ChengCheng Jiang, Yong Sun, Yuqing Zhang, Qingqing Chen, Hongliang He, Wenting Li, Jiajia Xie*, Zhirong Liu* Yong Gao*. Frontiers in Immunology. 2021 Aug 17;12:693775. 期刊论文. IF: 7.562. 2021 Aug 17;12:693775. 期刊论文
发布日期:2021-10-18浏览次数:
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Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has not been confirmed in altering viral antigenicity resulting in immune escape. To identify crucial mutations in spike protein that escape humoral immune response, we evaluated the cross-neutralization of convalescent plasmas and RBD-specific monoclonal antibodies (mAbs) against various spike protein-based pseudoviruses. Three of 24 SARS-CoV-2 pseudoviruses containing different mutations in spike protein, including D614G, A475V, and E484Q, consistently showed an altered sensitivity to neutralization by convalescent plasmas. A475V and E484Q mutants are highly resistant to neutralization by mAb B38 and 2-4, suggesting that some crucial mutations in spike protein might evolve SARS-CoV-2 variants capable of escaping humoral immune response.
上一篇:Employing Broadly Neutralizing Antibodies as a Human Immunodeficiency Virus Prophylactic & Therapeutic Application. Chengchao Ding, Darshit Patel, Yunjing Ma, Jamie F. S. Mann, Jianjun Wu, and Yong Gao*. Front Immunol. 2021 Jul 20;12:697683. IF : 7.562. 期刊论文
下一篇:Novel Monoclonal Antibodies and Recombined Antibodies Against Variant SARS-CoV-2. Jiajia Xie, Chengchao Ding, Jun He, Yuqing Zhang, Shuangshuang Ni, Xiangyu Zhang, Qingqing Chen, Jing Wang, Lina Huang, Hongliang He, Wenting Li, Huan Ma, Tengchuan Jin, Siping Zhang, Yong Gao. Front Immunol. 2021; 12: 715464. IF: 7.562. 期刊论文